Details

Autor(en) / Beteiligte

• Nahi, Hareth
• Smedmyr, Bengt
• Hallböök, Helene
• Hagglund, Hans

Titel

Do Deletions in 9p Reflect Prognosis in Adult Precursor B-Cell ALL? a Multi-Centre Study of 381 Patients

Ist Teil von

• Blood, 2008-11, Vol.112 (11), p.4865-4865

Ort / Verlag

Elsevier Inc

Erscheinungsjahr

2008

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Despite the fact that the outcome among patients with acute lymphoblastic leukaemia (ALL) has improved, the majority of adult patients relapse and die of their disease. Besides age and white cell count at diagnosis, the cytogenetic abnormalities t(9,22)/BCR-ABL and t(4,11) are important prognostic markers and are often included in the treatment stratification of patients with adult ALL. Deletions in 9p are seen in about 9% of cases of adult ALL, but their prognostic impact has been controversial. Methods: Cytogenetic data from 381 patients diagnosed with B-precursor ALL were reviewed. Chromosomal analysis was successful in 240 cases. Of these cases, 18 (8%) had abnormalities in 9p and they were compared with patients with normal karyotypes and patients with t(9;22)/BCR-ABL. Results: Patients with abnormalities of chromosome 9 showed significantly shorter overall survival compared with patients with normal karyotypes. In fact, overall survival was similar to that in the poor prognosis t(9;22)/BCR-ABL-positive group. Conclusions: The data suggest that chromosomal abnormalities involving 9p may have a significant negative impact on survival in adult B-precursor ALL.