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Three locomotives that overturned (toppled) during strong earthquakes (>6.5M) are used as computer analytical case studies. The locomotives were at rest or traveling very slowly at the time of the earthquakes. Fragility curves are presented relating ground shaking intensity to likelihood of toppling. Supplemental studies determine the influence of various parameters, including track gauge, damping, sway-roll period, and size effect. The shaking intensities necessary for standard gauge (56.5 in) locomotives to topple are much greater than the median intensities of 2475-year earthquakes representative of those in high seismic regions of the western United States. A general conclusion is that standard gauge locomotives at rest are not susceptible to toppling in such earthquakes (≪50% chance). This can be expected to be the case as well for freight and passenger cars having sizes and slenderness similar to the case study locomotives. The study also provides insights about the toppling fragility of other large unanchored objects having similar proportions.