Details

Autor(en) / Beteiligte

• Silchenko, Alexandra S.
• Kalinovsky, Anatoly I.
• Avilov, Sergey A.
• Andryjaschenko, Pelageya V.
• Dmitrenok, Pavel S.
• Yurchenko, Ekaterina A.
• Dolmatov, Igor Yu
• Savchenko, Alexander M.
• Kalinin, Vladimir I.

Titel

Triterpene Glycosides from the Sea Cucumber Cladolabes schmeltzii. II. Structure and Biological Action of Cladolosides A 1 -A 6

Ist Teil von

• Natural product communications, 2014-10, Vol.9 (10), p.1934578

Erscheinungsjahr

2014

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Six new triterpene glycosides, cladolosides A 1 –A 6 (1–6), have been isolated from the Vietnamese sea cucumber Cladolabes schmeltzii (Cladolabinae, Sclerodactylidae, Dendrochirotida). Structures of the glycosides were elucidated by 2D NMR spectroscopy and MS. All the glycosides have nonsulfated tetrasaccharide linear carbohydrate moieties. Glycoside 6 has a glucose residue as the third monosaccharide unit, while the rest of the compounds comprise a xylose in this postion of the carbohydrate chain. Glycosides 1–6 differ from each other in the structures of their holostane aglycones. Cytotoxic activities of glycosides 1–6 were studied against mouse spleenocytes, along with hemolytic activities against mouse erythrocytes. All the compounds, except cladoloside A 5 (5) posessing a hydroxy-group in the aglycone side chain, demonstrated rather strong cytotoxic and hemolytic effects. The most active glycosides were cladolosides A 1 (1) and A 2 (2) having two O-acetic groups and the xylose residue in the third position of the sugar chain.