Details

Autor(en) / Beteiligte

• Kicha, Alla A.
• Kalinovsky, Anatoly I.
• Antonov, Alexander S.
• Radchenko, Oleg S.
• Ivanchina, Natalia V.
• Malyarenko, Timofey V.
• Savchenko, Alexander M.
• Stonik, Valentin A.

Titel

Determination of C-23 Configuration in (20 R )-23-Hydroxycholestane Side Chain of Steroid Compounds by 1 H and 13 C NMR Spectroscopy

Ist Teil von

• Natural product communications, 2013-09, Vol.8 (9), p.1934578

Erscheinungsjahr

2013

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Epimeric (20 R,23 R)- and (20 R,23 S)-23-hydroxycholestane steroids were synthesized. Their structures were elucidated by extensive 1 H and 13 C NMR spectroscopy and application of the Mosher's method. All proton and carbon signals of the side chains were assigned. Based on these assignments spectral data allow the determination of the C-23 stereochemistry of (20 R)-23-hydroxycholestane side chains of the new natural steroids by comparison with spectra of the obtained model compounds. As a result, the C-23 configuration of two steroid compounds from the starfishes Lethasterias nanimensis chelifera and Lethasterias fusca was established.