Details

Autor(en) / Beteiligte

• Martínez, MCLR Díaz
• Martínez, A Díaz
• Salcedo, V Villamil
• Fuentes, C Cruz

Titel

Efficacy of Metadoxine in the Management of Acute Alcohol Intoxication

Ist Teil von

• Journal of international medical research, 2002-01, Vol.30 (1), p.44-51

Ort / Verlag

London, England: SAGE Publications

Erscheinungsjahr

2002

Quelle

MEDLINE

Beschreibungen/Notizen

• This randomized, open-label study evaluated the efficacy of 300 mg metadoxine (given intravenously) added to standard treatment compared with standard treatment alone in managing the physical and psychological signs of acute alcohol intoxication. Fifty-two acutely intoxicated patients were randomly assigned to one of two groups and followed during a 2-h period. Changes in clinical symptoms, degree of intoxication, and blood alcohol level were monitored. More patients receiving metadoxine in addition to standard therapy significantly improved by at least one degree of intoxication (one clinical category) compared with those receiving standard treatment alone (76.9% versus 42.3%, respectively). Metadoxinetreated patients also exhibited a significantly greater decrease in blood alcohol concentration compared with those receiving standard treatment alone (−105.4 ± 61.5 mg/dl versus −60.1 ± 38.6 mg/dl, respectively). Metadoxine improved the clinical signs of acute alcohol intoxication and accelerated alcohol clearance from the blood, thus supporting existing data. In contrast to previous data, these effects were concurrent but independent. No adverse effects were observed with metadoxine therapy.