Details

Autor(en) / Beteiligte

• Genschow, E
• Spielmann, H
• Scholz, G
• Pohl, I
• Seiler, A
• Clemann, N
• Bremer, S
• Becker, K

Titel

Validation of the embryonic stem cell test in the international ECVAM validation study on three in vitro embryotoxicity tests

Ist Teil von

• Alternatives to laboratory animals, 2004-09, Vol.32 (3), p.209-244

Ort / Verlag

England

Erscheinungsjahr

2004

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• A detailed report is presented on the performance of the embryonic stem cell test (EST) in a European Centre for the Validation of Alternative Methods (ECVAM)-sponsored formal validation study on three in vitro tests for embryotoxicity. Twenty coded test chemicals, classified as non-embryotoxic, weakly embryotoxic or strongly embryotoxic on the basis of their in vivo effects in animals and/or humans, were tested in four laboratories. The outcome showed that the EST can be considered to be a scientifically validated test, which is ready for consideration for use in assessing the embryotoxic potentials of chemicals for regulatory purposes.