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Association of Low Striatal Dopamine D 2 Receptor Availability With Nicotine Dependence Similar to That Seen With Other Drugs of Abuse
Ist Teil von
The American journal of psychiatry, 2008-04, Vol.165 (4), p.507-514
Ort / Verlag
American Psychiatric Association
Erscheinungsjahr
2008
Quelle
EZB Free E-Journals
Beschreibungen/Notizen
Objective:
All drugs of abuse induce a phasic dopamine release within the striatum that does not undergo habituation. Prolonged substance consumption impairs the natural function of the mesolimbic dopamine system, as shown by a decrease in the availability of striatal dopamine 2 (D
2
) receptors in patients suffering from cocaine, heroin, amphetamine, and alcohol dependence. However, it is unclear whether similar changes can also be observed in heavy-smoking nicotine-dependent smokers.
Method:
In vivo D
2
D
3
receptor availability was determined with [
18
F]fallypride positron emission tomography in 17 heavy-smoking nicotine-dependent subjects and in 21 age-matched never-smoking comparison subjects. The smokers were scanned twice: first, during a period of usual consumption and second, 24 hours after smoking cessation.
Results:
Independent of the withdrawal status, the nicotine-dependent smokers displayed significantly less availability of D
2
D
3
receptors within the bilateral putamen functionally covering parts of the dorsal striatum, as compared to the never-smoking subjects. Nicotine craving under the consumption condition correlated positively with D
2
D
3
receptor availability within the ventral striatum but negatively with D
2
D
3
receptor availability within the anterior cingulate and inferior temporal cortex.
Conclusions:
Similar to other types of substance abuse, nicotine dependence is associated with low availability of dorsal striatal D
2
D
3
receptors. In contrast to previous findings on abstinent alcohol-dependent patients, nicotine craving seems to be maintained by a region-specific shift in D
2
D
3
receptor availabilities, with higher availability within the ventral striatum but lower availability within the anterior cingulate and inferior temporal cortex.