Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Abstract P099: Fixed-dose Combination Therapy-based Protocol Compared With Nigeria’S National Hypertension Treatment Protocol: Results Of A Cluster Randomized Trial
Ist Teil von
Circulation (New York, N.Y.), 2022-03, Vol.145 (Suppl_1)
Erscheinungsjahr
2022
Link zum Volltext
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
Abstract only
Abstract Importance:
Out of the >1.2 billion adults with elevated blood pressure globally, treatment (42.5%) and control (20.5%) rates are very low, including in Nigeria, the most populous country in Africa. A treatment protocol that includes fixed-dose combination (FDC) therapy may improve hypertension control rates more efficiently and with no increase in adverse events compared with a standard treatment protocol.
Objective:
To determine the efficacy and safety of a treatment protocol that uses FDC therapy for hypertension control compared with Nigeria’s 2019 National Hypertension Treatment protocol from baseline to 6 months.
Design, setting, and participants:
Cluster randomized (1:1) trial among 60 primary health centers in Abuja, Nigeria, stratified by median case load and control rate. Eligible patients were adults (
>
18 years) who had a history of hypertension, persistently elevated blood pressure (SBP ≥140 mmHg or DBP ≥90 mmHg),or use of blood pressure lowering medications.
Interventions:
Sites were randomized to a protocol that started with and utilized 2- and 3-drug FDC therapy (Step 1: amlodipine 5 mg + losartan 50 mg) to a protocol that started with monotherapy (Step 1: amlodipine 5 mg) and added individuals medications.
Results:
Sixty sites, including 5,576 patients (mean [SD] age=49.2 [12.4] years; 70% female; mean [SD] baseline systolic/diastolic BP=155[SD]/96 [SD] mm Hg), were randomized. At 6-month follow-up, the rates of hypertension control for the FDC therapy and Nigeria’s 2019 National Hypertension Treatment protocol were 54.7% and 48.3%, respectively (
Figure 1
). The final results will be added at a later date.
Conclusion and relevance:
A hypertension treatment protocol that used FDC therapy led to a higher hypertension control rate compared with a standard treatment protocol in Nigeria. These results may have relevance to protocols used in other large-scale hypertension control programs.