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Abstract 19836: Lipid Metabolism is Modified by the Interaction Between Cholesteryl Ester Transfer Protein Gene Polymorphism and Mediterranean Diet in Patients in Secondary Prevention for Cardiovascular Disease
Ist Teil von
Circulation (New York, N.Y.), 2014-11, Vol.130 (suppl_2)
Erscheinungsjahr
2014
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Abstract only
Introduction:
Cholesteryl ester transfer protein (CETP) gene has been implicated in lipid metabolism. However, little is known about the impact of this gene on coronary heart disease (CHD) patients and its interaction with diet.
Hypothesis:
To evaluate whether the chronic consumption of a Mediterranean diet enriched in olive oil, compared with a Low fat diet, interacts with the
rs3764261
SNP at CETP locus in order to modify lipid metabolism among MetS patients from the CORDIOPREV clinical trial
Methods:
Plasma lipid concentrations and
rs3764261
genotypes were determined in 424 MetS subjects participating in the CORDIOPREV clinical trial. Gene-diet interactions were analyzed after a year of dietary intervention (Mediterranean diet (35% fat, 22% MUFA) vs Low fat
diet (28% fat, 12% MUFA))
Results:
We found significant gene-diet interactions between
rs3764261
SNP and the dietary pattern for HDL-C (
P=0.006
) and triglyceride concentrations (
P=0.040
). Specifically, after 12 months of Mediterranean diet intervention, subjects who were carriers of the minor T allele (TT+TG) displayed higher plasma HDL-C concentrations (
P=0.021
) and lower triglycerides (
P=0.020
) compared with homozygous for the major allele (GG). In contrast, in the Low fat intervention group no significant differences were found between CETP genotypes after 12 months of dietary treatment.
Conclusions:
Our data support the notion that a chronic consumption of a Mediterranean diet may play a contributing role in triggering lipid metabolism by interacting with the
rs3764261
SNP at CETP gene locus in MetS patients