Details

Autor(en) / Beteiligte

• Yamamoto, Keita
• Najima, Yuho
• Iizuka, Hiroko
• Harada, Yuka
• Sadato, Daichi
• Kanai, Akinori
• Matsui, Hirotaka
• Inamoto, Kyoko
• Mukae, Junichi
• Shingai, Naoki
• Toya, Takashi
• Igarashi, Aiko
• Shimizu, Hiroaki
• Kobayashi, Takeshi
• Kakihana, Kazuhiko
• Sakamaki, Hisashi
• Ohashi, Kazuteru
• Harada, Hironori
• Doki, Noriko

Titel

Successful Cord Blood Transplantation for Idiopathic CD4+ Lymphocytopenia

Ist Teil von

• Acta haematologica, 2021-11, Vol.144 (6), p.698-705

Ort / Verlag

Basel, Switzerland

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Idiopathic CD4 + lymphocytopenia (ICL) is the depletion of CD4 + lymphocytes to <300 cells/mm 3 without human immunodeficiency virus infection or other causes of lymphocytopenia. ICL causes fatal infections; its etiology remains unclear and it lacks consensus regarding therapeutic options. We report the first patient with ICL who had a successful clinical course following a cord blood transplant (CBT). A 45-year-old woman was diagnosed with ICL and underwent partial hepatectomy for an abscess caused by the Mycobacterium avium complex. No specific gene alterations were detected through next generation sequencing-based evaluation. Following a reduced-intensity conditioning (RIC) regimen consisting of fludarabine, busulfan, and 4 Gy total body irradiation, a single-unit CBT was performed. Neutrophils were engrafted on day +14. CD4 + lymphocyte counts increased to over 300 cells/mm 3 on day +436. After 75 months, she was alive without any sequelae. CBT with an RIC regimen could be a curable treatment option for ICL.