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Details

Autor(en) / Beteiligte
Titel
The Placenta as an Organ and a Source of Stem Cells and Extracellular Matrix: A Review
Ist Teil von
  • Cells, tissues, organs, 2016, Vol.201 (4), p.239-252
Ort / Verlag
Basel, Switzerland: S. Karger AG
Erscheinungsjahr
2016
Quelle
MEDLINE
Beschreibungen/Notizen
  • The placenta is a temporal, dynamic and diverse organ with important immunological features that facilitate embryonic and fetal development and survival, notwithstanding the fact that several aspects of its formation and function closely resemble tumor progression. Placentation in mammals is commonly used to characterize the evolution of species, including insights into human evolution. Although most placentas are discarded after birth, they are a high-yield source for the isolation of stem/progenitor cells and are rich in extracellular matrix (ECM), representing an important resource for regenerative medicine purposes. Interactions among cells, ECM and bioactive molecules regulate tissue and organ generation and comprise the foundation of tissue engineering. In the present article, differences among several mammalian species regarding the placental types and classifications, phenotypes and potency of placenta-derived stem/progenitor cells, placental ECM components and current placental ECM applications were reviewed to highlight their potential clinical and biomedical relevance.
Sprache
Englisch
Identifikatoren
ISSN: 1422-6405
eISSN: 1422-6421
DOI: 10.1159/000443636
Titel-ID: cdi_crossref_primary_10_1159_000443636

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