Details

Autor(en) / Beteiligte

• Chimenti, Maria Sole
• Teoli, Miriam
• Saraceno, Rosita
• Dattola, Annunziata
• Ventura, Alessandra
• Chiricozzi, Andrea
• Chiaramonte, Carlo
• Perricone, Roberto
• Chimenti, Sergio

Titel

Golimumab in patients affected by moderate to severe psoriatic arthritis: an open-label study in thirty-two patients previously treated with other biologics

Ist Teil von

• Dermatology (Basel), 2013-01, Vol.227 (4), p.305-310

Ort / Verlag

Switzerland

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• Clinical trials have demonstrated the efficacy of golimumab (GLB) in improving the signs and symptoms of psoriatic arthritis (PsA). The aim of this study was to evaluate the efficacy of GLB in monotherapy in patients affected by PsA with cutaneous involvement unresponsive to other anti-tumor necrosis factor-α (TNF-α) agents. This study included 32 patients treated with GLB as monotherapy, at a dosage of 50 mg, subcutaneously, every 4 weeks. Patients were divided into 3 groups (A, B, and C) according to their number of previous anti-TNF-α treatments (1, 2, or 3). Clinical and laboratory evaluations were performed at weeks 0, 12, and 24. All patients showed significant improvement of their clinical, inflammatory, and quality of life indexes. Data suggest that GLB can be successful and safe in patients affected by PsA with skin involvement previously treated with other anti-TNF-α agents.