Details

Autor(en) / Beteiligte

• Teodorescu, M.
• Sorocinschi, Florela
• Mogos, I.
• Brucher, J.
• Vasilescu, T.
• Moangă, M.

Titel

Factors Produced in Cultures of Human Lymphocytes Stimulated by Phytohemagglutinin (PHA)

Ist Teil von

• International archives of allergy and immunology, 1972-06, Vol.43 (6), p.826-836

Erscheinungsjahr

1972

Beschreibungen/Notizen

• PHA-stimulated human peripheral lymphocytes were cultivated in plasma-containing and in protein-free media. During the first 3 days of cultivation a skin-reactive factor (SRF) was released which, when inoculated i.d. in normal individuals, induced a tuberculin-like reaction 4 h after administration. SRF release is dependent only on blastic transformation of lymphocytes and not on their proliferation. An immunoelectrophoretic study of protein-free media revealed in all cultures, stimulated or not, the presence of a single precipitation band in the albumin area.