Details

Autor(en) / Beteiligte

• Ebeling, Peter
• Eisele, Lewin
• Schuett, Philipp
• Bauer, Sebastian
• Schuette, Jochen
• Moritz, Thomas
• Seeber, Siegfried
• Flasshove, Michael

Titel

Docetaxel and gemcitabine in the treatment of soft tissue sarcoma - a single-center experience

Ist Teil von

• Onkologie, 2008-01, Vol.31 (1-2), p.11-16

Ort / Verlag

Switzerland

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• Advanced stage/metastatic soft tissue sarcoma (STS) has a poor prognosis especially after failure of the established first-line treatment. In patients with relapsed leiomyosarcoma, however, the combination of gemcitabine (G) and docetaxel (D) recently has emerged as a valuable salvage therapy. A retrospective analysis of G (900 mg/m2, days 1+8) and D (100 mg/m2, day 8) was performed in 34 patients with STS, and response rate (RR), overall survival (OS), time to progression (TTP), and toxicities were evaluated. Analysis of these 34 patients revealed a RR of 15% with no complete remission (CR) and 5 partial remissions (PR). Of note, 4/5 PR were achieved in patients with leiomyosarcoma. In 13 patients (38%) disease stabilization (SD) could be achieved resulting in a clinical benefit rate (CBR), defined as CR+PR+SD, of 53%. Median OS was 12.5 and TTP was 2.4 months for the whole group and 2.8 months for patients with leiomyosarcoma. A progression- free rate at 3 months of 38% and 45%, respectively, was observed in these 2 groups. Major side effects were 47% hematological and 26% grade 3/4 nonhematological toxicity. With regard to the observed CBR further use of GD seems to be warranted even in pretreated patients with STS.