Details

Autor(en) / Beteiligte

• Heide, Rogier
• de Waard-van der Spek, Flora B
• den Hollander, Jan C
• Tank, Bhupendra
• Oranje, Arnold P

Titel

Efficacy of 25% diluted fluticasone propionate 0.05% cream as wet-wrap treatment in cutaneous mastocytosis

Ist Teil von

• Dermatology (Basel), 2007-01, Vol.214 (4), p.333-335

Ort / Verlag

Switzerland

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• Mastocytosis is a disorder that can be subdivided into two forms: cutaneous and systemic. Patients with cutaneous mastocytosis only may suffer from cosmetic problems. Topical steroid application has been shown to be effective in cases of limited skin lesions. A case-controlled pilot study was conducted during a 6-weeks treatment using diluted 25% fluticasone propionate 0.05% cream under wet-wrap occlusion in 5 adults and 6 children. Improvement was measured up to the 24th week after treatment using the SCORMA Index. The results of this pilot study showed a partial but clear cosmetic improvement in 9 of the 11 patients. The mean SCORMA Index decreased after treatment from 38 to 26. 25% dilution of fluticasone propionate 0.05% cream under wet-wrap occlusion is an alternative treatment modality for alleviating the symptoms of cutaneous mastocytosis, but the improvement may be moderate and fall short of the patient's expectations.