Details

Autor(en) / Beteiligte

• Pateras, Ioannis S
• Apostolopoulou, Kalliopi
• Niforou, Katerina
• Kotsinas, Athanassios
• Gorgoulis, Vassilis G

Titel

p57KIP2: “Kip”ing the Cell under Control

Ist Teil von

• Molecular cancer research, 2009-12, Vol.7 (12), p.1902-1919

Ort / Verlag

United States: American Association for Cancer Research

Erscheinungsjahr

2009

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek (Open access)

Beschreibungen/Notizen

• p57 KIP2 is an imprinted gene located at the chromosomal locus 11p15.5. It is a cyclin-dependent kinase inhibitor belonging to the CIP/KIP family, which includes additionally p21 CIP1/WAF1 and p27 KIP1 . It is the least studied CIP/KIP member and has a unique role in embryogenesis. p57 KIP2 regulates the cell cycle, although novel functions have been attributed to this protein including cytoskeletal organization. Molecular analysis of animal models and patients with Beckwith-Wiedemann Syndrome have shown its nodal implication in the pathogenesis of this syndrome. p57 KIP2 is frequently down-regulated in many common human malignancies through several mechanisms, denoting its anti-oncogenic function. This review is a thorough analysis of data available on p57 KIP2 , in relation to p21 CIP1/WAF1 and p27 KIP1 , on gene and protein structure, its transcriptional and translational regulation, and its role in human physiology and pathology, focusing on cancer development. (Mol Cancer Res 2009;7(12):1902–19)