Details

Autor(en) / Beteiligte

• Halle, Mari Kyllesø
• Hodneland, Erlend
• Hoivik, Erling
• Wagner-Larsen, Kari
• Lura, Njål G.
• Dybvik, Julie
• Forsse, David
• Bertelsen, Bjørn I.
• Krakstad, Camilla
• Haldorsen, Ingfrid S.
• Bozickovic, Olivera
• Woie, Kathrine

Titel

Abstract 513: Radiomic profiles revealing targets for therapy in cervical cancer

Ist Teil von

• Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.513-513

Erscheinungsjahr

2022

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Abstract Magnetic resonance imaging (MRI) has emerged as an important part of the diagnostic work-up in cervical cancer, with tumor volume and extent as important prognosticators. MRI radiomic tumor features may aid in prognostication and tailoring of treatment in cervical cancer. We extracted whole-volume radiomic texture features from 124 manually segmented tumors and performed unsupervised clustering yielding two distinct clusters. Overlapping clinicopathologic, genomic (whole exome sequencing, n=61), transcriptomic (L1000 arrays, n= 65) and molecular biomarker (n=82) data were applied to characterize the clusters. Independent of tumor size parameters, patients in cluster II had significantly reduced disease-specific survival as compared to those in cluster I (p>0.001), also within squamous cell carcinomas (n=96, p<0.001). Cluster II associated with high age (p=0.02), high FIGO-2009 stage (p<0.001), high BMI (p=0.03) and PR negative tumors (p=0.004). Distinct mutational and copy-number profiles were detected for the two clusters. By gene set enrichment analyses, gene sets associated to immune activation were enriched in cluster I tumors, whilst gene sets associated with oxidative phosphorylation and epithelial to mesenchymal transition associated to cluster II tumors. This study links radiomic signatures to distinct genomic profiles that may potentially aid in prognostication and tailoring of treatments in cervical cancer patients. Citation Format: Mari Kyllesø Halle, Erlend Hodneland, Erling Hoivik, Kari Wagner-Larsen, Njål G. Lura, Julie Dybvik, David Forsse, Bjørn I. Bertelsen, Camilla Krakstad, Ingfrid S. Haldorsen, Olivera Bozickovic, Kathrine Woie. Radiomic profiles revealing targets for therapy in cervical cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 513.