Details

Autor(en) / Beteiligte

• Singh, Karnika
• Jones, Melanie
• Moscatello, Augustine
• Shin, Edward
• Tiwari, Raj
• Geliebter, Jan

Titel

Abstract 1288: Does an increased underlying immune/inflammatory response in healthy females put them at a higher risk for thyroid cancer

Ist Teil von

• Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.1288-1288

Erscheinungsjahr

2015

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Abstract The SEER (Surveillance, Epidemiology, and End Results Program) and American Cancer Society data indicate that the incidence of papillary thyroid cancer is ∼ 3 times greater in females, as compared to males. The American Cancer Society estimates that out of a total of ∼62,980 new thyroid cancer cases in 2014, approximately 47,790 of these will be women. There is strong evidence that supports the role of estrogen in the pathogenesis of thyroid cancer. Estrogen also plays a critical role in the inflammatory process. For example, mouse models have demonstrated that in vivo exposure to estrogen promotes an inflammatory response, including the enhanced secretion of Th-1 related cytokines (IFNγ, IL-12, IL-1β) and inflammatory chemokines (MCP-1 and MCP-5). Studies in rats and mouse models have shown that females exhibit stronger humoral and cellular immune responses as compared to males. As the association between inflammation and cancer is widely accepted, we hypothesize that an underlying immune and inflammatory response in the normal female thyroid puts it at a higher risk of developing cancer. The Cancer Genome Atlas (TCGA) provides a means to assess gender differences at the molecular level. Using the SUBIO platform version 1.17 (SUBIO Inc., Amami Island, Japan), we performed bioinformatics and statistical analyses on the Level 3 RNA-Seq data available in the TCGA Data Portal. Differential gene expression analysis of 39 normal thyroid samples (26 females and 13 males) revealed that out of the 20,531 genes analyzed, 73 genes exhibited >2 fold increased expression in females vs. males (p-value, 0.05). Of these 73 genes, 10 genes were involved in immune response and inflammation. We are currently analyzing expression levels of these genes on the RNA and protein levels. Such analysis will help us to elucidate a possible link between the gender disparity in thyroid cancer and inflammation. Citation Format: Karnika Singh, Melanie Jones, Augustine Moscatello, Edward Shin, Raj Tiwari, Jan Geliebter. Does an increased underlying immune/inflammatory response in healthy females put them at a higher risk for thyroid cancer. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1288. doi:10.1158/1538-7445.AM2015-1288