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Evaluation of Risk Factors for Nasopharyngeal Carcinoma in High-Risk Nasopharyngeal Carcinoma Families in Taiwan
Ist Teil von
Cancer epidemiology, biomarkers & prevention, 2005-04, Vol.14 (4), p.900-905
Ort / Verlag
Philadelphia, PA: American Association for Cancer Research
Erscheinungsjahr
2005
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
A study of nasopharyngeal carcinoma (NPC) families with two or more affected members was conducted in Taiwan (265 families
with 2,444 individuals, 502 affected and 1,942 unaffected) to determine the association between NPC and potential etiologic
factors in NPC high-risk families. Similar to results from a previous case-control study in Taiwan, Guangdong salted fish
consumption during childhood, exposure to wood, and betel nut consumption were all associated with elevated NPC risk using
conditional logistic regression, although these associations were not as strong as in the case-control study possibly due
to shared environment among family members. Risk associated with cumulative wood exposure and salted fish consumption before
age 10 was stronger in families with early NPC age-onset [odds ratio (OR wood ), 5.10; 95% confidence interval (95% CI), 1.50-17.34; OR fish , 3.94; 95% CI, 1.47-10.55] or three or more affected members (OR wood , 4.41; 95% CI, 1.58-12.30; OR fish , 4.27; 95% CI, 1.10-16.47). In contrast, a tendency for elevated risk was noted for betel nut use in late age-onset families
(OR, 2.44; 95% CI, 1.16-5.13) and the CYP2E1 c2 allele in families with less than three affected members (OR, 2.06; 95% CI, 1.04-3.35). Risk estimates associated with these
exposures were similar when the analyses were restricted to EBV-seropositive subjects. To better adjust for degree of relationship
among family members and residual genetic correlations, we also calculated ORs using a variance components model. The results
from the two methods were similar indicating that the risk estimates from conditional logistic regression were unbiased.