Details

Autor(en) / Beteiligte

• Sato, N
• Shen, Y. T
• Kiuchi, K
• Shannon, R. P
• Vatner, S. F

Titel

Splenic contraction-induced increases in arterial O2 reduce requirement for CBF in conscious dogs

Ist Teil von

• American journal of physiology. Heart and circulatory physiology, 1995-08, Vol.269 (2), p.H491-H503

Ort / Verlag

United States

Erscheinungsjahr

1995

Quelle

MEDLINE

Beschreibungen/Notizen

• N. Sato, Y. T. Shen, K. Kiuchi, R. P. Shannon and S. F. Vatner Department of Medicine, Harvard Medical School, Boston 02115, USA. We investigated the extent to which sympathomimetic amines induced splenic contraction and associated increases in arterial O2 content (CaO2) and how these mechanisms affected control of the coronary circulation by sympathomimetic amines in conscious dogs. Blood hemoglobin (Hb) and CaO2 increased by 16 +/- 2 and 18 +/- 2%, respectively, during norepinephrine (NE, 0.8 micrograms.kg-1.min-1 iv) in the intact, conscious state after splenic contraction. Phenylephrine (PE) induced similar effects. After either alpha 1-adrenergic-receptor blockade or splenectomy, these effects were abolished. Isoproterenol (Iso) also decreased splenic thickness, which was abolished after ganglionic, alpha-, or beta 1/beta 2-adrenergic-receptor blockade. Direct infusions of NE and PE into the splenic artery decreased splenic thickness and increased Hb and CaO2, whereas Iso had no effect. After splenectomy, NE did not increase CaO2, but coronary blood flow (CBF) increased more (73 +/- 6%) vs. before splenectomy (49 +/- 7%) without any differences before and after splenectomy in the responses of pressures, contractility, and myocardial O2 consumption (MVO2). In contrast, renal, mesenteric, and iliac artery blood flows were not significantly different in response to sympathomimetic amines before and after splenectomy. These data indicate that sympathomimetic amines induced splenic contraction either directly or reflexly via alpha-adrenergic-receptor stimulation. The consequent increase in Hb and CaO2 allows for equivalent increases in MVO2, but at a smaller increase in CBF.