Details

Autor(en) / Beteiligte

• Gertsenshteyn, Inna
• Epel, Boris
• Barth, Eugene
• Leoni, Lara
• Markiewicz, Erica
• Tsai, Hsiu-Ming
• Fan, Xiaobing
• Giurcanu, Mihai
• Bodero, Darwin
• Zamora, Marta
• Sundramoorthy, Subramanian
• Kim, Heejong
• Freifelder, Richard
• Bhuiyan, Mohammed
• Kucharski, Anna
• Karczmar, Gregory
• Kao, Chien-Min
• Halpern, Howard
• Chen, Chin-Tu

Titel

Improving Tumor Hypoxia Location in 18 F-Misonidazole PET with Dynamic Contrast-enhanced MRI Using Quantitative Electron Paramagnetic Resonance Partial Oxygen Pressure Images

Ist Teil von

• Radiology. Imaging cancer, 2021-03, Vol.3 (2), p.e200104

Ort / Verlag

United States

Erscheinungsjahr

2021

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• To enhance the spatial accuracy of fluorine 18 ( F) misonidazole (MISO) PET imaging of hypoxia by using dynamic contrast-enhanced (DCE) MR images as a basis for modifying PET images and by using electron paramagnetic resonance (EPR) partial oxygen pressure (pO ) as the reference standard. Mice ( = 10) with leg-borne MCa4 mammary carcinomas underwent EPR imaging, T2-weighted and DCE MRI, and F-MISO PET/CT. Images were registered to the same space for analysis. The thresholds of hypoxia for PET and EPR images were tumor-to-muscle ratios greater than or equal to 2.2 mm Hg and less than or equal to 14 mm Hg, respectively. The Dice similarity coefficient (DSC) and Hausdorff distance (d ) were used to quantify the three-dimensional overlap of hypoxia between pO EPR and F-MISO PET images. A training subset ( = 6) was used to calculate optimal DCE MRI weighting coefficients to relate EPR to the PET signal; the group average weights were then applied to all tumors (from six training mice and four test mice). The DSC and d were calculated before and after DCE MRI-corrected PET images were obtained to quantify the improvement in overlap with EPR pO images for measuring tumor hypoxia. The means and standard deviations of the DSC and d between hypoxic regions in original PET and EPR images were 0.35 mm ± 0.23 and 5.70 mm ± 1.7, respectively, for images of all 10 mice. After implementing a preliminary DCE MRI correction to PET data, the DSC increased to 0.86 mm ± 0.18 and the d decreased to 2.29 mm ± 0.70, showing significant improvement ( < .001) for images of all 10 mice. Specifically, for images of the four independent test mice, the DSC improved with correction from 0.19 ± 0.28 to 0.80 ± 0.29 ( = .02), and the d improved from 6.40 mm ± 2.5 to 1.95 mm ± 0.63 ( = .01). Using EPR information as a reference standard, DCE MRI information can be used to correct F-MISO PET information to more accurately reflect areas of hypoxia. Animal Studies, Molecular Imaging, Molecular Imaging-Cancer, PET/CT, MR-Dynamic Contrast Enhanced, MR-Imaging, PET/MR, Breast, Oncology, Tumor Mircoenvironment, Electron Paramagnetic Resonance © RSNA, 2021.