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Annual review of microbiology, 2015-10, Vol.69 (1), p.405-423
Ort / Verlag
United States: Annual Reviews
Erscheinungsjahr
2015
Quelle
MEDLINE
Beschreibungen/Notizen
Mycobacterium tuberculosis
remains one of the most successful bacterial pathogens, claiming over 1.3 million lives worldwide in 2013. The emergence of multidrug-resistant and extensively drug-resistant isolates has prompted the need for new drugs and drug targets.
M. tuberculosis
possesses an unusual cell wall dominated by lipids and carbohydrates that provides a permeability barrier against hydrophilic drugs and is crucial for its survival and virulence. This large macromolecular structure, termed the mycolyl-arabinogalactan-peptidoglycan complex, and the phosphatidyl-
myo
-inositol-based lipoglycans are key features of the mycobacterial cell wall. Assembly of these cell wall components is an attractive target for the development of chemotherapeutics against tuberculosis. Herein, we focus on recent biochemical and molecular insights into these complex molecules of
M. tuberculosis
cell wall.