Details

Autor(en) / Beteiligte

• Hruska, F. E
• Ogilvie, K. K
• Smith, A. A
• Wayborn, H

Titel

Molecular Conformation of 4-Thiouridine in Aqueous Solution

Ist Teil von

• Canadian journal of chemistry, 1971-07, Vol.49 (14), p.2449-2452

Ort / Verlag

Ottawa, Canada: NRC Research Press

Erscheinungsjahr

1971

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• β-4-Thiouridine is a component of several tRNA molecules. A recent X-ray study has shown that this pyrimidine nucleoside favors the syn conformation in the crystalline state. The 100 and 220 MHz p.m.r. data and a comparison with those of uridine are presented here. A long-range five-bond spin-spin coupling interaction between the H-5 and -1′ hydrogens is noted. The results are consistent with an anti conformation for 4-thiouridine in an aqueous solution.