Details

Autor(en) / Beteiligte

• Nishimura, Yoshiaki
• Igarashi, Tatsuhiko
• Buckler-White, Alicia
• Buckler, Charles
• Imamichi, Hiromi
• Goeken, Robert M.
• Lee, Wendy R.
• Lafont, Bernard A. P.
• Byrum, Russ
• Lane, H. Clifford
• Hirsch, Vanessa M.
• Martin, Malcolm A.

Titel

Loss of Naïve Cells Accompanies Memory CD4 + T-Cell Depletion during Long-Term Progression to AIDS in Simian Immunodeficiency Virus-Infected Macaques

Ist Teil von

• Journal of virology, 2007-01, Vol.81 (2), p.893-902

Erscheinungsjahr

2007

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• ABSTRACT Human immunodeficiency virus and simian immunodeficiency virus (SIV) induce a slow progressive disease, characterized by the massive loss of memory CD4 + T cells during the acute infection followed by a recovery phase in which virus replication is partially controlled. However, because the initial injury is so severe and virus production persists, the immune system eventually collapses and a symptomatic fatal disease invariably occurs. We have assessed CD4 + T-cell dynamics and disease progression in 12 SIV-infected rhesus monkeys for nearly 2 years. Three macaques exhibiting a rapid progressor phenotype experienced rapid and irreversible loss of memory, but not naïve, CD4 + T lymphocytes from peripheral blood and secondary lymphoid tissues and died within the first 6 months of virus inoculation. In contrast, SIV-infected conventional progressor animals sustained marked but incomplete depletions of memory CD4 + T cells and continuous activation/proliferation of this T-lymphocyte subset. This was associated with a profound loss of naïve CD4 + T cells from peripheral blood and secondary lymphoid tissues, which declined at rates that correlated with disease progression. These data suggest that the persistent loss of memory CD4 + T cells, which are being eliminated by direct virus killing and activation-induced cell death, requires the continuous differentiation of naïve into memory CD4 + T cells. This unrelenting replenishment process eventually leads to the exhaustion of the naïve CD4 + T-cell pool and the development of disease.