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Science (American Association for the Advancement of Science), 1973-10, Vol.182 (4107), p.78-79
Erscheinungsjahr
1973
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
In patients with vitamin B
12
deficiency, phytohemagglutinin-stimulated cultured lymphocytes had little or no thymidylate synthetase activity. Ample activity was found in such lymphocytes from normal individuals and patients with folic acid deficiency or pernicious anemia in remission. It therefore appears that the megaloblastosis that is associated with vitamin B
12
deficiency is related to low thymidylate synthetase activity.