Science (American Association for the Advancement of Science), 2001-08, Vol.293 (5534), p.1491-1495
2001
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Details
- Autor(en) / Beteiligte
- Titel
- Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils
- Ist Teil von
- Science (American Association for the Advancement of Science), 2001-08, Vol.293 (5534), p.1491-1495
- Ort / Verlag
- Washington, DC: American Society for the Advancement of Science
- Erscheinungsjahr
- 2001
- Quelle
- American Association for the Advancement of Science
- Beschreibungen/Notizen
- β-Amyloid plaques and neurofibrillary tangles (NFTs) are the defining neuropathological hallmarks of Alzheimer's disease, but their pathophysiological relation is unclear. Injection of β-amyloid Aβ42fibrils into the brains of P301L mutant tau transgenic mice caused fivefold increases in the numbers of NFTs in cell bodies within the amygdala from where neurons project to the injection sites. Gallyas silver impregnation identified NFTs that contained tau phosphorylated at serine 212/threonine 214 and serine 422. NFTs were composed of twisted filaments and occurred in 6-month-old mice as early as 18 days after Aβ42injections. Our data support the hypothesis that Aβ42fibrils can accelerate NFT formation in vivo.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.1062097Titel-ID: cdi_crossref_primary_10_1126_science_1062097
- Format
- –
- Schlagworte
- Alzheimers disease, Amygdala, Antibodies, B lymphocytes, Biological and medical sciences, Degeneration, Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases, Epitopes, Genetically modified mice, Health aspects, Injection sites, Medical sciences, Nervous system, Neurofibrils, Neurology, Neurons, Protein isoforms, Solar fibrils, Transgenic animals