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Functional patterns of cytomegalovirus ( CMV ) pp65 and immediate early‐1‐specific CD 8 + T cells that are associated with protection from and control of CMV DNA emia after allogeneic stem cell transplantation
Abstract
Background
The functional profile of cytomegalovirus (
CMV
)‐specific
CD
8
+
T cells that associate with protection from and control of
CMV DNA
emia in allogeneic stem cell transplant (allo‐
SCT
) recipients remains incompletely characterized.
Methods
We enumerated pp65 and immediate early (
IE
)‐1‐specific
CD
8
+
T cells expressing interferon‐gamma, tumor necrosis factor‐alpha, and
CD
107a, by flow cytometry in 94 patients at days +30 and +60 after allo‐
SCT
.
Results
Fifty of 94 patients had
CMV DNA
emia within the first 100 days after transplant.
CMV
‐specific
CD
8
+
T‐cell responses (of any functional type) were more likely to be detected in patients who did not display
CMV DNA
emia than in those who did (
P
= 0.04). Qualitatively, no major differences in the functional signature of
CMV
‐specific
CD
8
+
T cells were noted between patients who had or did not have
CMV DNA
emia. Patients displaying levels of polyfunctional
CD
8
+
T cells at day +30 >0.30 cell/μL had a lower risk of
CMV DNA
emia (positive predictive value 76%, and negative predictive value 43%).
Conclusion
The presence of polyfunctional
CD
8
+
T cells (either expressing
CD
107a or not) was associated with lower levels of
CMV
replication, and higher frequency of self‐resolved episodes. The data reported further clarify the role of polyfunctional
CD
8
+
T cells in control of
CMV DNA
emia in allo‐
SCT
recipients.
Sprache
Englisch
Identifikatoren
ISSN: 1398-2273
eISSN: 1399-3062
DOI: 10.1111/tid.12391
Titel-ID: cdi_crossref_primary_10_1111_tid_12391
Format
–
Weiterführende Literatur
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