Details

Autor(en) / Beteiligte

• LI, Dan‐dan
• CHEN, Jun‐hua
• CHEN, Qing
• LI, Guo‐wei
• CHEN, Jing
• YUE, Jian‐min
• CHEN, Min‐li
• WANG, Xiao‐ping
• SHEN, Jian‐hua
• SHEN, Xu
• JIANG, Hua‐liang

Titel

Swietenia mahagony extract shows agonistic activity to PPAR γ and gives ameliorative effects on diabetic db/db mice

Ist Teil von

• Acta pharmacologica Sinica, 2005-02, Vol.26 (2), p.220-222

Ort / Verlag

Oxford, UK: Blackwell Science Pty

Erscheinungsjahr

2005

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Aim: To search the peroxisome proliferator‐activated receptor γ (PPARγ) agonists from Swietenia mahagony extract (SmE) and observe the possible ameliorative effects of SmE on diabetic db/db mice. Methods: The PPARγ agonistic activity of SmE was screened by yeast‐two hybrid system. The blood glucose levels of diabetic db/db mice were measured using a blood glucose level monitor and the data were statistically analyzed by NDST8.8W software. Results: By using the clinical drug rosiglitazone as a positive control, it was found that the PPARγ agonistic activity of SmE at a concentration of 50 μg/L was approximately half that of 35.7 μg/L (0.1 μmol/L) of rosiglitazone. At the dose of 1000 mg/kg, SmE remarkably decreased the blood glucose concentration of db/db mice from (15.26±2.98) to (7.58±2.20) mmol/L, and reduced the blood glucose levels by 55.49% compared with the control group (P<0.01). Conclusion: SmE shows agonistic activity to PPARγ and can ameliorate the blood glucose levels of diabetic db/db mice. SmE may be thus used as a potential agent for diabetes therapy.