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Interactions Between the Apolipoprotein A 1/ C 3/ A 5 Haplotypes and Alcohol Consumption on Serum Lipid Levels
Ist Teil von
Alcoholism, clinical and experimental research, 2013-02, Vol.37 (2), p.234-243
Erscheinungsjahr
2013
Link zum Volltext
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
Background
The interactions between apolipoprotein (
A
po)
A
1/
C
3/
A
5 haplotypes and alcohol consumption on serum lipid profiles have not been previously explored. The present study was undertaken to detect the polymorphisms of
A
po
A
1 −75 bp
G
>
A
(rs1799837),
A
po
C
3 3238
C
>
G
(rs5128),
A
po
A
5 −1131
T
>
C
(rs662799),
A
po
A
5 c.553
G
>
T
(rs2075291), and
A
po
A
5 c.457
G
>
A
(rs3135507) and the interactions between their haplotypes and alcohol consumption on serum lipid levels.
Methods
Genotyping was performed in 1,030 unrelated subjects (516 nondrinkers and 514 drinkers) aged 15 to 89. The interactions between
A
po
A
1/
C
3/
A
5 haplotypes and alcohol consumption on serum lipid levels were detected by factorial regression analysis after controlling for potential confounders.
Results
The frequencies of
A
po
C
3 3238
CG
/
GG
genotypes and
A
po
A
1 −75 bp
A
allele in nondrinkers were higher in females than in males (
p
< 0.05). The frequencies of
A
po
C
3 3238
CG
/
GG
genotypes and
G
allele in drinkers were higher in females than in males (
p
< 0.05). The frequencies of
A
po
A
1 −75 bp
GA
/
AA
genotypes and
A
allele in males were higher, and those of
A
po
C
3 3238
CG
/
GG
genotypes were lower in drinkers than in nondrinkers (
p
< 0.05 to 0.01). The frequency of
A
po
C
3 3238
GG
genotype in male drinkers was also higher in ≥25 g/d than in <25 g/d subgroups (
p
< 0.05). There were 11 haplotypes with a frequency >1% in our study population. The haplotypes of
G
–
G
–
T
–
C
–
G
(in the order of c.553
G
>
T
, c.457
G
>
A
, −1131
T
>
C
, 3238
C
>
G
, and −75 bp
G
>
A
),
G
–
G
–
T
–
C
–
A
, and
G
–
G
–
C
–
G
–
G
were shown consistent interactions with alcohol consumption to increase serum total cholesterol, high‐density lipoprotein cholesterol (
HDL
‐
C
), and ApoA1 levels (
p
< 0.05 to 0.001). The interactions between
G
–
G
–
T
–
G
–
G
(
HDL
‐
C
and
A
po
A
1),
G
–
G
–
C
–
C
–
A
(
A
po
A
1),
G
–
A
–
T
–
C
–
G
(triglyceride),
G
–
G
–
T
–
C
–
G
(
A
po
A
1/
A
po
B
ratio), and
G
–
G
–
C
–
G
–
G
(
A
po
B
) haplotypes and alcohol consumption on serum lipid levels were also detected (
p
< 0.05 to 0.001); the levels of these serum lipid parameters were significantly higher in drinkers than in nondrinkers.
Conclusions
The differences in serum lipid parameters between drinkers and nondrinkers might partly result from different interactions between the
A
po
A
1/
C
3/
A
5 haplotypes and alcohol consumption.