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Summary
Identifying the genes that influence risk for genetically complex epilepsies is a major challenge for the next decade. This chapter reviews possible biologic mechanisms, methodologic approaches, and findings from recent studies aimed at gene identification in complex epilepsies, and approaches for clarifying phenotype definition for genetic research on the epilepsies. For an expanded treatment of this topic see Jasper’s Basic Mechanisms of the Epilepsies, Fourth Edition (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado‐Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at http://www.ncbi.nlm.nih.gov/books).