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B cell activation through CD 40 and IL 4R ligation modulates the response of chronic lymphocytic leukaemia cells to BAFF and APRIL
Ist Teil von
British journal of haematology, 2014-02, Vol.164 (4), p.570-578
Erscheinungsjahr
2014
Quelle
Wiley Online Library
Beschreibungen/Notizen
Summary
The two tumour necrosis factor family proteins
BAFF
(
TNFSF
13B) and
APRIL
(
TNFSF
13) and their receptors [
BAFF
‐R (
TNFRSF
13C),
TACI
(
TNFRSF
13B),
BCMA
(
TNFRSF
17)] play a critical role in the survival of normal B cells. The sensitivity of normal B cells to
BAFF
and
APRIL
can be modulated by signals regulated by their receptors. This modulation, however, has not been extensively investigated in chronic lymphocytic leukaemia (
CLL
) cells. We evaluated the expression, regulation and signalling of
BAFF
and
APRIL
receptors in normal and in
CLL
cells upon stimulation through
CD
40+
IL
4R and
BCR
. We further analysed the prognostic value of
BAFF
and
APRIL
receptors expression in patients with
CLL
.
BCMA
expression was significantly higher on
CLL
cells than on normal B cells.
BCR
and
CD
40+
IL
4R stimulation promoted an increase in
TACI
and
BCMA
expression, cell viability and activation in normal B cells. A similar effect was observed in
CLL
cells after
CD
40+
IL
4R but not
BCR
stimulation.
BCMA
expression correlated with unmutated
IGHV
genes, poor‐risk cytogenetics, and short progression‐free survival. These findings further characterize the link between
CD
40+
IL
4R regulatory signals,
BAFF
,
APRIL
and their receptors and the survival of leukaemic cells and clinical features of
CLL
.
Sprache
Englisch
Identifikatoren
ISSN: 0007-1048
eISSN: 1365-2141
DOI: 10.1111/bjh.12645
Titel-ID: cdi_crossref_primary_10_1111_bjh_12645
Format
–
Weiterführende Literatur
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