Details

Autor(en) / Beteiligte

• Amelard, Robert
• Robertson, Andrew D.
• Patterson, Courtney A.
• Heigold, Hannah
• Saarikoski, Essi
• Hughson, Richard L.

Titel

Optical Hemodynamic Imaging of Jugular Venous Dynamics During Altered Central Venous Pressure

Ist Teil von

• IEEE transactions on biomedical engineering, 2021-08, Vol.68 (8), p.2582-2591

Ort / Verlag

United States: IEEE

Erscheinungsjahr

2021

Link zum Volltext

• IEEE_Xplore

Quelle

IEEE Xplore Digital Library

Beschreibungen/Notizen

• Objective: An optical imaging system is proposed for quantitatively assessing jugular venous response to altered central venous pressure. Methods: The proposed system assesses sub-surface optical absorption changes from jugular venous waveforms with a spatial calibration procedure to normalize incident tissue illumination. Widefield frames of the right lateral neck were captured and calibrated using a novel flexible surface calibration method. A hemodynamic optical model was derived to quantify jugular venous optical attenuation (JVA) signals, and generate a spatial jugular venous pulsatility map. JVA was assessed in three cardiovascular protocols that altered central venous pressure: acute central hypovolemia (lower body negative pressure), venous congestion (head-down tilt), and impaired cardiac filling (Valsalva maneuver). Results: JVA waveforms exhibited biphasic wave properties consistent with jugular venous pulse dynamics when time-aligned with an electrocardiogram. JVA correlated strongly (median, interquartile range) with invasive central venous pressure during graded central hypovolemia (r = 0.85, [0.72, 0.95]), graded venous congestion (r = 0.94, [0.84, 0.99]), and impaired cardiac filling (r = 0.94, [0.85, 0.99]). Reduced JVA during graded acute hypovolemia was strongly correlated with reductions in stroke volume (SV) (r = 0.85, [0.76, 0.92]) from baseline (SV: 79<inline-formula><tex-math notation="LaTeX">\,\pm\,</tex-math></inline-formula>15 mL, JVA: 0.56<inline-formula><tex-math notation="LaTeX">\,\pm\,</tex-math></inline-formula>0.10 a.u.) to <inline-formula><tex-math notation="LaTeX">-</tex-math></inline-formula>40 mmHg suction (SV: 59<inline-formula><tex-math notation="LaTeX">\,\pm\,</tex-math></inline-formula>18 mL, JVA: 0.47<inline-formula><tex-math notation="LaTeX">\,\pm\,</tex-math></inline-formula>0.05 a.u.; p<inline-formula><tex-math notation="LaTeX">\,<\, </tex-math></inline-formula>0.01). Conclusion: The proposed non-contact optical imaging system demonstrated jugular venous dynamics consistent with invasive central venous monitoring during three protocols that altered central venous pressure. Significance: This system provides non-invasive monitoring of pressure-induced jugular venous dynamics in clinically relevant conditions where catheterization is traditionally required, enabling monitoring in non-surgical environments.