Details

Autor(en) / Beteiligte

• Drechsler, Hauke
• McAinsh, Andrew D.

Titel

Exotic mitotic mechanisms

Ist Teil von

• Open biology, 2012-12, Vol.2 (12), p.120140-120140

Ort / Verlag

England: The Royal Society

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• The emergence of eukaryotes around two billion years ago provided new challenges for the chromosome segregation machineries: the physical separation of multiple large and linear chromosomes from the microtubule-organizing centres by the nuclear envelope. In this review, we set out the diverse solutions that eukaryotic cells use to solve this problem, and show how stepping away from ‘mainstream’ mitosis can teach us much about the mechanisms and mechanics that can drive chromosome segregation. We discuss the evidence for a close functional and physical relationship between membranes, nuclear pores and kinetochores in generating the forces necessary for chromosome segregation during mitosis.