Details

Autor(en) / Beteiligte

• Kronenberger, Bernd
• Berg, Thomas
• Herrmann, Eva
• Hinrichsen, Holger
• Gerlach, Tilman
• Buggisch, Peter
• Spengler, Ulrich
• Goeser, Tobias
• Nasser, Samer
• Wursthorn, Karsten
• Pape, Gerd R
• Hopf, Uwe
• Zeuzem, Stefan

Titel

Efficacy of amantadine on quality of life in patients with chronic hepatitis C treated with interferon-α and ribavirin: results from a randomized, placebo-controlled, double-blind trial

Ist Teil von

• European journal of gastroenterology & hepatology, 2007-08, Vol.19 (8), p.639-646

Ort / Verlag

Hagerstown, MD: Lippincott Williams & Wilkins, Inc

Erscheinungsjahr

2007

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• AIMThe aim of this study was to investigate whether amantadine reduces deterioration of quality of life in patients with chronic hepatitis C during and after treatment with interferon-α (IFN-α) and ribavirin. PATIENTS AND METHODSIn this randomized, prospective, placebo-controlled, multicenter trial, previously untreated patients with chronic hepatitis C were treated with IFN-α plus ribavirin [] and randomized for treatment with amantadine (200 mg/day, orally, n=136) or placebo (n=131). Quality of life was assessed with the ‘Profile of Mood States’ scale and the ‘Everyday Life’ questionnaire at baseline, treatment week (TW) 8, TW24, TW48, and at follow-up. RESULTSEarly during treatment at TW8, quality of life was not different between patients in the control and the amantadine group. At TW24, the control group but not the amantadine group, however, showed significant deterioration of the modalities depression, fatigue, and vigor compared with baseline. Especially, nonresponders in the amantadine group showed significantly lower deterioration of depression, anger, mind function, everyday life, and zest for life than those in the placebo group. After treatment, the beneficial effects of amantadine disappeared. CONCLUSIONThe addition of amantadine to IFN-α plus ribavirin combination therapy may reduce deterioration of depression, fatigue, and vigor during treatment but does not affect quality of life after treatment.