Details

Autor(en) / Beteiligte

• Chakraborty, Rana
• Smith, Colette J
• Dunn, David
• Green, Hannah
• Duong, Trinh
• Doerholt, Katja
• Riordon, Andrew
• Lyall, Hermione
• Tookey, Pat
• Butler, Karina
• Sabin, Caroline A
• Gibb, Di
• Pillay, Deenan

Titel

HIV-1 DRUG RESISTANCE IN HIV-1-INFECTED CHILDREN IN THE UNITED KINGDOM FROM 1998 TO 2004

Ist Teil von

• The Pediatric infectious disease journal, 2008-05, Vol.27 (5), p.457-459

Ort / Verlag

Baltimore, MD: Lippincott Williams & Wilkins, Inc

Erscheinungsjahr

2008

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• We reviewed HIV-1 genotypes from 200 of 979 (20%) HIV-infected children in the U.K. Collaborative HIV in Pediatric Study (CHIPS) cohort (343 resistance tests). Three of 44 samples had major primary resistance mutations before antiretroviral therapy. Three-class resistance was noted in 42 samples (14.1%). Our study also highlighted underutilization of testing and the need for prompt genotyping after drug discontinuation which may have lead to an underestimation of HIV-1 resistance.