Details

Autor(en) / Beteiligte

• Wijnands, José M.A
• Boonen, Annelies
• van Sloten, Thomas T
• Schram, Miranda T
• Sep, Simone J.S
• Koster, Annemarie
• van der Kallen, Carla J.H
• Henry, Ronald M.A
• Dagnelie, Pieter C
• Stehouwer, Coen D.A
• van der Linden, Sjef
• Arts, Ilja C.W

Titel

Association between serum uric acid, aortic, carotid and femoral stiffness among adults aged 40–75 years without and with type 2 diabetes mellitus: The Maastricht Study

Ist Teil von

• Journal of hypertension, 2015-08, Vol.33 (8), p.1642-1650

Ort / Verlag

England: Copyright Wolters Kluwer Health, Inc. All rights reserved

Erscheinungsjahr

2015

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• OBJECTIVE:Arterial stiffness may be a mechanism to explain the association between uric acid and cardiovascular disease. We aimed to analyse associations between serum uric acid and regional and local arterial stiffness, and assess potential differences related to sex and glucose metabolism status. METHODS:A cross-sectional study was performed in 614 adults [52.6% men; mean age 58.7 ± 8.5 years; 23.2% type 2 diabetes mellitus (by design)] from The Maastricht Study. Arterial stiffness was assessed by carotid–femoral pulse wave velocity (cfPWV), distensibility, and compliance coefficient of the carotid and femoral artery, and carotid artery Youngʼs elastic modulus. RESULTS:Higher uric acid (per SD of 74 μmol/l) was associated with greater stiffness indicated by a significantly higher cfPWV [β = 0.216 (95% confidence interval 0.061, 0.372); P = 0.006] and lower carotid distensibility coefficient [β = −0.633 (95% confidence interval −1.099, −0.166); P = 0.008] after adjustment for sex, age, and glucose metabolism status. Associations lost significance after adjusting for mean arterial pressure, BMI, waist, smoking status, heart rate, total : high-density lipoprotein cholesterol ratio, triglycerides, estimated glomerular filtration rate, use of lipid-lowering, antihypertensive, and diabetes medication, and use of secondary uricosurics. No associations were found between uric acid and carotid compliance coefficient, carotid Youngʼs elastic modulus, or stiffness of the femoral artery. A significant interaction (P < 0.10) with glucose metabolism status was found for cfPWV. However, none of the stratified associations were significant. There was no interaction with sex. CONCLUSION:Uric acid was not significantly associated with stiffness of the aorta, or the carotid or femoral artery among adults aged 40–75 years without and with type 2 diabetes mellitus.