Details

Autor(en) / Beteiligte

• Taja-Chayeb, Lucia
• González-Fierro, Aurora
• Miguez-Muñoz, Cristian
• Trejo-Becerril, Catalina
• Cruz-Hernandez, Erick de la
• Cantu, David
• Agundez, Jose A
• Vidal-Millan, Silvia
• Gutierrez, Olga
• Dueñas-González, Alfonso

Titel

Acetylator status and N-acetyltransferase 2 gene polymorphisms; phenotype–genotype correlation with the sulfamethazine test

Ist Teil von

• Pharmacogenetics and genomics, 2011-12, Vol.21 (12), p.894-901

Ort / Verlag

Hagerstown, MD: Lippincott Williams & Wilkins, Inc

Erscheinungsjahr

2011

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• N-acetyltransferase 2 (NAT2) catalyzes the bioactivation and/or detoxification of drugs and carcinogens. The aim of this study was to establish the correlation between the NAT2 genotype and the acetylating phenotype in a Mexican population using sulfamethazine as a probe. From a total of 122 individuals, 73 (59.8%) were slow and 49 (40.2%) were fast acetylators. Eleven individuals (9%) had the wild-type genotype (NAT2*4/NAT2*4). The most frequent genotype was NAT2*4/NAT2*5B observed in 20.66% of individuals. In conclusion, our results show that an accurate prediction of the acetylation phenotype by genotyping can be achieved in around half of the population. Further studies with a larger number of individuals are required to establish correlations between phenotype and genotype in half of that patients having a genotype combined with slow/rapid alleles.