Details

Autor(en) / Beteiligte

• LUCHT, Michael J
• KUEHN, Kail U
• FREYBERGER, Harald J
• SCHROEDER, Winnie
• ARMBRUSTER, Jan
• ABRAHAM, Gerit
• SCHATTENBERG, Andreas
• GAENSICKE, Michael
• BARNOW, Sven
• TRETZEL, Horst
• HERRMANN, Falko H

Titel

Influence of the dopamine D2 receptor (DRD2) exon 8 genotype on efficacy of tiapride and clinical outcome of alcohol withdrawal

Ist Teil von

• Pharmacogenetics (London), 2001-11, Vol.11 (8), p.647-653

Ort / Verlag

Hagerstown, MD: Lippincott Williams and Wilkins

Erscheinungsjahr

2001

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• We tested the hypothesis that allelic variants of the human dopamine D2 receptor E8 genotype are associated with (i) dopamine D2 antagonist tiapride dose in treatment of alcohol withdrawal (n = 50) and (ii) with anxiety and depression in patients during alcoholism detoxification therapy (admission n = 87; discharge n = 50). DRD2 E8 A/A genotype was associated with increased dose of tiapride during a 9-day detoxification therapy and with increased anxiety and depression scores on admission and 2 weeks later. The findings suggest a pharmacogenetic influence of DRD2 E8 genotype on tiapride efficacy in alcohol withdrawal. In an earlier report, DRD2 E8 A/A genotype was associated with reduced responsiveness to the dopamine D2 agonist apomorphine; however, it is not clear whether both findings share the same biological basis. Earlier findings concerning association of DRD2 E8 A/A with increased anxiety and depression are replicated for the first time.