Details

Autor(en) / Beteiligte

• Calvo, Mona
• Beelman, Robert
• Mehrotra, Anita
• Nadkarni, Girish
• Wang, Lingzhi
• Boon Cher, Goh
• Uribarri, Jaime

Titel

Risk factor modification in pre‐diabetic adults consuming white button mushrooms rich in the anti‐oxidant, ergothioneine (117.4)

Ist Teil von

• The FASEB journal, 2014-04, Vol.28 (S1), p.n/a

Ort / Verlag

The Federation of American Societies for Experimental Biology

Erscheinungsjahr

2014

Link zum Volltext

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Oxidative stress & vitamin D (vitD) deficiency increase reactive oxygen species & low‐grade inflammation contributing to type 2 diabetes (T2D). To determine the effects of nutrition intervention with an antioxidant from WBM on T2D risk, we conducted 20 analyses of results from a study of health effects of vitD‐enriched‐WBM in pre‐diabetics. Group vitD intakes varied, but had no influence on oxidative risk factors. All of the 37 pre‐diabetic subjects consumed 100g WBM/d for 4 m in this study, enabling us to assess changes from baseline of risk factors associated with ergothioneine (ergo) antioxidant intake from WBM. As shown below, we used paired‐t‐tests to assess significant change from baseline for serum ergo & biomarkers of risk at 4 m (P1), and at 5 m (P2) [1m after diet ended]. Early analyses show significant (P<0.01) decreases from baseline of pro‐oxidant, advanced glycation end products with WBM‐ergo intake. Significant increases from baseline occurred for serum ergo, adiponectin & ORAC, at 4 & at 5 m, for all but ORAC. We conclude WBM are bioavailable food sources for the antioxidant ergo in older pre‐diabetic adults & their consumption effectively modifies risk factors for T2D. Changes of biomarkers during the study Biomarker Baseline 4 months 5 months p1 p2 Isoprostane 178±88 166±72 176±79 .38 .71 Leptin 24.3±14.3 24.9±15.6 24±14 .95 .98 Adiponectin 7.9±3.2 8.8±3.5 9.5±4.3 .02 .02 ORAC 5570±1683 6088±1696 5740±1523 .02 .70 Ergothioneine 317±163 677±497 496±340 .01 .01