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Bioavailability and metabolomic targets of sulforaphane in humans (1036.2)
Ist Teil von
The FASEB journal, 2014-04, Vol.28 (S1), p.n/a
Ort / Verlag
The Federation of American Societies for Experimental Biology
Erscheinungsjahr
2014
Link zum Volltext
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
Sulforaphane (SFN), an isothiocyanate derived from cruciferous vegetables, has many potential health benefits. Yet, there is limited knowledge about its bioavailability and biological functions in humans. Crucifers contain glucoraphanin (GFN), which is hydrolyzed to SFN by myrosinase (MYR). Study objectives were to determine SFN bioavailability and examine metabolomic profiles in plasma following consumption of a MYR‐treated broccoli sprout extract (BSE) supplement and broccoli sprouts. We have previously shown a 7‐fold decrease in SFN bioavailability from GFN supplements with inactivated MYR than from broccoli sprouts, suggesting MYR activity impacts SFN bioavailability. SFN bioavailability from BSEs was improved over MYR‐inactivated GFN supplements but was ~3 times lower than sprouts. High‐throughput metabolomic analysis revealed alterations in plasma metabolites following SFN consumption. Unique metabolomic profiles following BSE and sprout consumption suggested differential metabolic responses from the supplemental and whole‐food forms of SFN. BSE and sprout consumption was associated with unique biochemical targets, and several common targets of the two SFN forms were altered in opposite directions. This research provides important information for conducting SFN supplementation studies to understand SFN’s role in disease prevention.
Grant Funding Source: Supported by R01CA122906, P01CA090890, P30 ES000210