Details

Autor(en) / Beteiligte

• Sandoval, Christopher L
• Wilson, Robert W
• Gopalakrishnan, Sandeep
• Lark, Daniel S
• Eells, Janis T
• Snyder, Ann C

Titel

670 nm LED Treatment Affects Hyperglycemia‐Induced Oxidative Stress in Skeletal Muscle in Diabetic Rats

Ist Teil von

• The FASEB journal, 2008-03, Vol.22 (S1)

Erscheinungsjahr

2008

Link zum Volltext

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Abstract only Oxidative stress is important in the pathogenesis of diabetes‐induced muscle atrophy. Low energy photon irradiation with 670 nm light has been shown to attenuate oxidative stress following ischemia‐reperfusion injury in the heart. PURPOSE: To determine if 670 nm LED treatment (NIR) would attenuate oxidative damage in a model of type I diabetes, the streptozotocin (STZ)‐treated rat. METHODS: Wistar rats were divided into three treatment groups: Control (CON), STZ‐treated (STZ) and 670 nm LED treated STZ (NIR‐STZ). Diabetes was induced by STZ (50 mg/kg, ip). NIR‐STZ animals were treated once per day for 5 min for 17 days with 670 nm LED arrays (6 joules/cm2; QDI, Barneveld, WI). Animals were euthanized on day 18 and the rectus femoris (RF) muscle was dissected and flash frozen for biochemical analysis of lipid peroxidation. RESULTS: Lipid peroxidation in the RF was slightly increased in the STZ and NIR‐STZ groups relative to control. Total antioxidant capacity in the RF was increased in STZ and NIR‐STZ rats when compared to that of the CON. CONCLUSIONS: Hyperglycemia increased the production of reactive oxygen species. In the acute stage of diabetes, antioxidant proteins are upregulated in response to oxidative stress and protect against lipid peroxidation. Diabetic animals treated with 670 nm light exhibited an additional increase in antioxidant capacity. Funded by: Biomedical Technology Alliance Award and UWM RGI.