Details

Autor(en) / Beteiligte

• Sasaki, Shigeki
• Yamauchi, Hiroyuki
• Takahasi, Ryo
• Taniguchi, Yousuke
• Maeda, Minoru

Titel

New base analogs for the formation of non-natural triplexes

Ist Teil von

• Nucleic Acids Symposium Series, 2001-11, Vol.1 (1), p.23-24

Ort / Verlag

Oxford University Press

Erscheinungsjahr

2001

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Novel nucleoside analogs have been designed for selective formation of antiparallel triplexes including a TA or a CG interrupting site. The new compounds are constructed of a W-shape bicyclic nucleic acid (WNA) bearing an aromatic ring as a stacking motif and a guanine for the formation of Hoogesteen hydrogen bonds, and are expected to effect triplex stabilization by both stacking and complementary hydrogen bonds. Purine-rich triplex-forming oligodeoxynucleotide (TFO) incorporating the new analog, WNA-7βG, formed a stable triplex with high selectivity to the AT site.