Details

Autor(en) / Beteiligte

• Ripoll, Laurent
• Reinert, Philippe
• Pépin, Louis-Ferdinand
• Lagrange, Philippe H.

Titel

Interaction of macrolides with adornase during DNA hydrolysis

Ist Teil von

• Journal of antimicrobial chemotherapy, 1996-05, Vol.37 (5), p.987-991

Ort / Verlag

Oxford University Press

Erscheinungsjahr

1996

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Since patients with cystic fibrosis are often treated with adornase to reduce sputum viscosity, and because of preliminary reports of efficacy of long-term low-dose erythromycin therapy in chronic airway diseases, it is likely that adornase and macrolides might be given together in such patients. A possible interaction between these drugs was therefore investigated. Using hyperchromic effect to quantify adornase activity, a time- and dose-dependent inhibitory effect on human DNA hydrolysis has been observed for erythromycin, roxithromycin and azithromycin. Inhibitory doses 50% for adornase were graphically determined. Azithromycin exhibited the strongest inhibitory effect.