Details

Autor(en) / Beteiligte

• Mascart-Lemone, F
• Gérard, M
• Libin, M
• Crusiaux, A
• Franchioly, P
• Lambrechts, A
• Goldman, M
• Clumeck, N

Titel

Differential effect of human immunodeficiency virus infection on the IgA and IgG antibody responses to pneumococcal vaccine

Ist Teil von

• The Journal of infectious diseases, 1995-11, Vol.172 (5), p.1253-1260

Ort / Verlag

United States

Erscheinungsjahr

1995

Quelle

MEDLINE

Beschreibungen/Notizen

• The IgA, IgM, and IgG antibody responses to pneumococcal polysaccharide vaccine were analyzed in 35 asymptomatic or mildly symptomatic human immunodeficiency virus (HIV)-infected patients stratified according to their CD4 cell counts and in 12 healthy controls. Both the antibody titers in serum and saliva and the numbers of circulating antigen-specific antibody-producing cells (Elispot technique) were measured. At the peak of the antibody responses, HIV-infected patients mounted nearly normal IgG responses, while their IgM responses were significantly depressed, regardless of their CD4 cell counts. The IgA antibody response was decreased in patients with < 500 CD4 circulating cells/mm3. Most IgG antibodies belonged to the IgG2 subclass, and most IgA antibodies were dimeric IgA2 in both controls and patients. Anti-capsular pneumococcal polysaccharide IgG titers decreased much more rapidly in HIV-infected patients so that in all groups they were significantly lower than in controls 9 months after vaccination.