Details

Autor(en) / Beteiligte

• Nantsupawat, T
• Apaijai, N
• Prommintikul, A
• Prasertwitayakij, N
• Chattipakorn, S
• Chattipakorn, N
• Wongcharoen, W

Titel

Oxidative stress and mitochondrial function among various types of atrial fibrillation

Ist Teil von

• Europace (London, England), 2024-05, Vol.26 (Supplement_1)

Erscheinungsjahr

2024

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract Introduction Mitochondrial dysfunction has been shown to be associated with atrial fibrillation (AF) in previous studies. Purpose We aimed to determine mitochondrial function in various AF types and AF burden to further delineate whether mitochondrial function has graded or quantal response relationship with AF. Methods This is a cross-sectional study in patients with atrial high-rate episode (AHRE) or AF who have dual-chamber cardiovascular implantable electronic device (CIED). Patients were categorized into clinical AF and subclinical AF. AF burden was measured as AHRE via CIED interrogations. Oxidative stress and mitochondrial function were determined in peripheral blood mononuclear cells (PBMCs). Results There was a total of 54 CIED patients. Mean age was 69.9+12.8 years. There were 9 (16.7%) patients with diabetes mellitus and 36 (66.7%) patients with history of clinical AF. After adjusting with multiple linear regression for age, left ventricular ejection fraction, glomerular filtration rate, history of AF, and diabetes mellitus, we found that clinical AF, as compared to subclinical AF, was independently associated with lower non-mitochondrial respiration (20.8, 6.5-35.6 vs. 48.0, 14.0-60.9 pMol/min, p=0.021) (median, IQR); lower basal respiration (72.1, 47.4-94.4 vs.97.2, 52.1-152.6 pMol/min, p=0.020); and lower ATP production (57.3, 24.7-73.2 vs. 78.6, 45.7-112.0 pMol/min, p=0.014) (Table 1). However, AF burden was not associated with alterations in oxidative stress and mitochondrial function. Conclusions Mitochondrial function from PBMC was significantly lower in patients with clinical AF compared to those with subclinical AF. However, there was no association between AF burden and the change in mitochondrial function. The study revealed a quantal response relationship between PBMC’s mitochondrial function and AF.