Carcinogenesis (New York), 1993-09, Vol.14 (9), p.1733-1735
1993
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Details
- Autor(en) / Beteiligte
- Titel
- Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA
- Ist Teil von
- Carcinogenesis (New York), 1993-09, Vol.14 (9), p.1733-1735
- Ort / Verlag
- Oxford: Oxford University Press
- Erscheinungsjahr
- 1993
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The endogenous production of oxidative damage in DNA by free radicals released as a by-product of respiration is a likely cause of mutations which, if they occur in appropriate genes, may lead to cancer. Using an endonuclease specific for oxidized pyrimidines, in conjunction with the highly sensitive method of single cell gel electrophoresis, we have detected significant oxidative damage in untreated, freshly isolated lymphocytes from normal, healthy individuals.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0143-3334eISSN: 1460-2180DOI: 10.1093/carcin/14.9.1733Titel-ID: cdi_crossref_primary_10_1093_carcin_14_9_1733
- Format
- –
- Schlagworte
- Biological and medical sciences, Carcinogenesis, carcinogens and anticarcinogens, DNA Damage, DNA, Superhelical - analysis, DNA, Superhelical - drug effects, Electrophoresis, Agar Gel - methods, Endodeoxyribonucleases, General aspects, HeLa Cells, Humans, Hydrogen Peroxide - pharmacology, Lymphocytes - chemistry, Medical sciences, Oxidation-Reduction, Tumors