Details

Autor(en) / Beteiligte

• Curigliano, G.
• Disalvatore, D.
• Esposito, A.
• Pruneri, G.
• Lazzeroni, M.
• Guerrieri-Gonzaga, A.
• Luini, A.
• Orecchia, R.
• Goldhirsch, A.
• Rotmensz, N.
• Bonanni, B.
• Viale, G.

Titel

Risk of subsequentin situ and invasive breast cancer in human epidermal growth factor receptor 2-positive ductal carcinomain situ

Ist Teil von

• Annals of oncology, 2015-04, Vol.26 (4), p.682-687

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2015

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• HER2 overexpression in primary ductal carcinomain situ (DCIS) was associated with a higher risk of in situ recurrence. No association with a higher risk of invasive breast cancer recurrence was observed. Our data have shown a clear benefit from radiotherapy in HER2-positive DCIS. To assess the prognostic role of human epidermal growth factor receptor 2 (HER2) overexpression in patients with ductal carcinomain situ (DCIS). We identified patients with HER2-positive DCIS among a population of 1667 cases, prospectively diagnosed and surgically treated at the European Institute of Oncology from 1996 to 2008. Rates of subsequent DCIS or invasive cancer in HER2-positive disease were estimated. We evaluated Cumulative Incidence ofIn Situ Breast Cancer Recurrence (isBCR), INvasive Breast Cancer Recurrence (IBCR) and any Breast Cancer Recurrence (BCR).isBCR, IBCR and BCR were defined as the time from surgery to breast cancer recurrence as first event (in situ, invasive or both, respectively) or last visit in case of no events. We identified 560 (33.5%) patients with HER2-positive DCIS. The median follow-up was 7.6 years (interquartile range 5.9–9.5). We observed 422 events out of 1667 patients, with 141in situ recurrences, 201 invasive recurrences and 80 other events (64 second primaries and 16 deaths). The 10-yearisBCR proportions were 11.8% [95% confidence interval (CI) 9.0% to 15.4%] in the HER2-positive group and 8.8% (95% CI 6.9% to 11.0%) in the HER2-negative group (Gray test,P = 0.010). At multivariable analysis, the adjusted risk ofisBCR was higher in the HER2-positive group than in the HER2-negative group [hazard ratio (HR) HER2 positive versus negative: 1.59 (95% CI 1.06–2.39)]. We observed significant differences both in BCR and isBCR for patients treated by quadrantectomy without radiotherapy versus patients treated with radiotherapy [adjusted HR HER2 positive versus negative: 1.53 (95% CI 1.07–2.18) and adjusted HR HER2 positive versus negative: 2.18 (95% CI 2.18–3.69), respectively]. HER2 overexpression predicts an increased risk ofisBCR. Radiotherapy reduces local failure rates in HER2-positive DCIS.