Details

Autor(en) / Beteiligte

• Shin, A.
• Park, S.
• Shin, H.R.
• Park, E.-H.
• Park, S.K.
• Oh, J.-K.
• Lim, M.-K.
• Choi, B.Y.
• Boniol, M.
• Boffetta, P.

Titel

Population attributable fraction of infection-related cancers in Korea

Ist Teil von

• Annals of oncology, 2011-06, Vol.22 (6), p.1435-1442

Ort / Verlag

Oxford: Elsevier Ltd

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• A number of infectious agents have been classified as human carcinogens. The purpose of the current study was to provide an evidence-based assessment of the burden of infection-related cancers in the Korean population. The population attributable fraction was calculated using infection prevalence data from 1990 or earlier, relative risk estimates from meta-analyses using mainly Korean studies and national data on cancer incidence and mortality for the year 2007. The fractions of all cancers attributable to infection were 25.1% and 16.8% for cancer incidence in men and women, and 25.8% and 22.7% of cancer mortality in men and women, respectively. Among infection-related cancers, Helicobacter pylori was responsible for 56.5% of cases and 45.1% of deaths, followed by hepatitis B virus (HBV) (23.9% of cases and 37.5% of deaths) and human papillomavirus (HPV) (11.3% of cases and 6% of deaths) and then by hepatitis C virus (HCV) (6% of cases and 9% of deaths). Over 97% of infection-related cancers were attributable to infection with H. pylori, HBV, HCV and HPV. Up to one-quarter of cancer cases and deaths would be preventable through appropriate control of infectious agents in Korea.