Details

Autor(en) / Beteiligte

• Fuh, Martin M.-T.
• Lee, May M.S.
• Jeng, Chii-Y.
• Ma, Frances
• Chen, Y.-D. Ida
• Reaven, Gerald M.

Titel

Effect of Low Fat – High Carbohydrate Diets in Hypertensive Patients With Non – Insulindependent Diabetes Mellitus

Ist Teil von

• American journal of hypertension, 1990-07, Vol.3 (7), p.527-532

Ort / Verlag

Oxford University Press

Erscheinungsjahr

1990

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Effects of variations in dietary fat and carbohydrate content on various aspects of glucose, insulin, and lipoprotein metabolism were evaluated in 11 patients with hypertension, who also had non – insulindependent diabetes mellitus (NIDDM). All of these patients were being treated with sulfonylureas, thiazides, and β-adrenergic receptor antagonists. The comparison diets contained either 40 or 60% of total calories as carbohydrate, with reciprocal changes in fat content from 40 to 20%. The diets were consumed in a random order for 15 days in a crossover experimental design. The ratio of polyunsaturated to saturated fat and total cholesterol intake were held constant in the two diets. Plasma glucose and insulin concentrations were significantly (P < .001) elevated throughout the day when patients consumed the 60% carbohydrate diet. Fasting plasma total and very-low-density lipoprotein (VLDL) and triglyceride (TG) concentrations increased by 30% (P < .001) after 15 days on the 60% carbohydrate diet. Total plasma cholesterol concentrations were similar on both diets, as were low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol concentrations. Am J Hypertens 1990;3:527–532