Details

Autor(en) / Beteiligte

• Diness, Birgitte Rode
• Christoffersen, Dorthe
• Pedersen, Ulla Britt
• Rodrigues, Amabelia
• Fischer, Thea Kolsen
• Andersen, Andreas
• Whittle, Hilton
• Yazdanbakhsh, Maria
• Aaby, Peter
• Benn, Christine Stabell

Titel

The Effect of High-Dose Vitamin A Supplementation Given with Bacille Calmette-Guérin Vaccine at Birth on Infant Rotavirus Infection and Diarrhea: A Randomized Prospective Study from Guinea-Bissau

Ist Teil von

• The Journal of infectious diseases, 2010-09, Vol.202 (Supplement-1), p.S243-S251

Ort / Verlag

United States: The University of Chicago Press

Erscheinungsjahr

2010

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Background. Prophylactic vitamin A supplementation (VAS) reduces mortality and may reduce morbidity associated with diarrhea in children >6 months of age. Rotavirus is the most common cause of acute dehydrating diarrhea among children worldwide. Methods. In a randomized placebo-controlled study of 50,000 IU of vitamin A versus placebo given with bacille Calmette-Gue'rin vaccine at birth, 287 infants were followed up with weekly interviews and stool sample obtainment to test the hypothesis that VAS reduced the risk of rotavirus infection. Results. VAS was associated with increased risk of rotavirus infection and diarrhea (incidence rate ratio [IRR] of infection, 1.72 [95% confidence interval (CI), 1.04–2.85]; IRR of diarrhea, 3.74 [95% CI, 1.40–9.98]) among children <6 months of age. There was no effect in older children. VAS had a beneficial effect on nonrotavirus diarrhea in boys <6 months of age (IRR, 0.51; 95% CI, 0.27–0.95) and a detrimental effect in girls >6 months of age (IRR, 1.84; 95% CI, 0.96-3.55). Conclusion. VAS at birth did not reduce rotavirus morbidity. The effect of VAS on nonrotavirus diarrhea may differ by sex, being more beneficial in boys. Clinical trials registration. NCT00168597.